Medulloblastoma development: tumor biology informs treatment decisions
نویسندگان
چکیده
منابع مشابه
Medulloblastoma: Tumor Biology and Relevance to Treatment and Prognosis Paradigm.
Medulloblastoma is a malignant embryonic brain tumor arising in the posterior fossa and typically occurring in pediatric patients. Current multimodal treatment regimes have significantly improved the survival rates; however, a marked heterogeneity in therapy response is observed, and one third of all patients die within 5 years after diagnosis. Large-scale genetic and transcriptome analysis rev...
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While medulloblastoma, a pediatric tumor of the cerebellum, is characterized by aberrations in developmental pathways, the majority of genetic determinants remain unknown. An unbiased Sleeping Beauty transposon screen revealed MyoD as a putative medulloblastoma tumor suppressor. This was unexpected, as MyoD is a muscle differentiation factor and not previously known to be expressed in cerebellu...
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ژورنال
عنوان ژورنال: CNS Oncology
سال: 2015
ISSN: 2045-0907,2045-0915
DOI: 10.2217/cns.14.58